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Check Intently (1)pentobarbital will decrease the extent or influence of fentanyl transdermal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to your lessen in fentanyl plasma concentrations, deficiency of efficacy or, probably, enhancement of the